Paralog specific Hsp90 Inhibitors – a brief history and a bright future

per Gewirth, Daniel T.
Publicat a Curr Top Med Chem (2016)

Structural basis of VDR–DNA interactions on direct repeat response elements

per Shaffer, Paul L., Gewirth, Daniel T.
Publicat 2002

Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer

per Fiandalo, Michael V., Gewirth, Daniel T., Mohler, James L.
Publicat a Asian J Urol (2019)

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96: A POTENTIAL THERAPEUTIC TARGET FOR CANCER METASTASIS

per Hong, Feng, Liu, Bei, Chiosis, Gabriela, Gewirth, Daniel T., Li, Zihai
Publicat 2013

Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones

per Dollins, D. Eric, Warren, Joshua J., Immormino, Robert M., Gewirth, Daniel T.
Publicat 2007

Structural and functional analysis of GRP94 in the closed state reveals an essential role for the pre-N domain and a potential client-binding site

per Huck, John D., Que, Nanette S., Hong, Feng, Li, Zihai, Gewirth, Daniel T.
Publicat a Cell Rep (2017)

Structural basis of androgen receptor binding to selective androgen response elements

per Shaffer, Paul L., Jivan, Arif, Dollins, D. Eric, Claessens, Frank, Gewirth, Daniel T.
Publicat 2004

Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide

per Williams, Allison H., Immormino, Robert M., Gewirth, Daniel T., Raetz, Christian R. H.
Publicat 2006

The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain

per Wu, Shuang, Hong, Feng, Gewirth, Daniel, Guo, Beichu, Liu, Bei, Li, Zihai
Publicat 2012

Characterization of the Grp94/OS-9 chaperone-lectin complex

per Seidler, Paul M., Shinsky, Stephen A., Hong, Feng, Li, Zihai, Cosgrove, Michael S., Gewirth, Daniel T.
Publicat 2014

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity

per Huck, John D., Que, Nanette L.S., Sharma, Sahil, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.
Publicat a Proteins (2019)

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

per Huck, John D., Que, Nanette L. S., Immormino, Robert M., Shrestha, Liza, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.
Publicat a J Biol Chem (2019)

Different Poses for Ligand and Chaperone in Inhibitor Bound Hsp90 and GRP94: Implications for Paralog-specific Drug Design

per Immormino, Robert M., Metzger, Louis E., Reardon, Patrick N., Dollins, D. Eric, Blagg, Brian S.J., Gewirth, Daniel T.
Publicat 2009

Structure based design of a Grp94-selective inhibitor: Exploiting a key residue in Grp94 to optimize paralog-selective binding

per Que, Nanette L. S., Crowley, Vincent M., Duerfeldt, Adam S., Zhao, Jinbo, Kent, Caitlin N., Blagg, Brian S. J., Gewirth, Daniel T.
Publicat a J Med Chem (2018)

Chaperome heterogeneity and its implications for cancer study and treatment

per Wang, Tai, Rodina, Anna, Dunphy, Mark P., Corben, Adriana, Modi, Shanu, Guzman, Monica L., Gewirth, Daniel T., Chiosis, Gabriela
Publicat a J Biol Chem (2019)

Exploring the Functional Complementation between Grp94 and Hsp90

per Maharaj, Kevin A., Que, Nanette L. S., Hong, Feng, Huck, John D., Gill, Sabrina K., Wu, Shuang, Li, Zihai, Gewirth, Daniel T.
Publicat a PLoS One (2016)

The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membran...

per Alam, S. Munir, McAdams, Mildred, Boren, David, Rak, Michael, Scearce, Richard M., Gao, Feng, Camacho, Zenaido T., Gewirth, Daniel, Kelsoe, Garnett, Chen, Pojen, Haynes, Barton F.
Publicat 2007

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

per Taldone, Tony, Patel, Pallav D., Patel, Maulik, Patel, Hardik J., Evans, Christopher E., Rodina, Anna, Ochiana, Stefan, Shah, Smit K., Uddin, Mohammad, Gewirth, Daniel, Chiosis, Gabriela
Publicat 2013

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of Her2

per Patel, Pallav D., Yan, Pengrong, Seidler, Paul M., Patel, Hardik J., Sun, Weilin, Yang, Chenghua, Que, Nanette S., Taldone, Tony, Finotti, Paola, Stephani, Ralph A., Gewirth, Daniel T., Chiosis, Gabriela
Publicat 2013

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94

per Ansa-Addo, Ephraim A., Thaxton, Jessica, Hong, Feng, Wu, Bill X., Zhang, Yongliang, Fugle, Caroline W., Metelli, Alessandra, Riesenberg, Brian, Williams, Katelyn, Gewirth, Daniel T., Chiosis, Gabriela, Liu, Bei, Li, Zihai
Publicat a Curr Top Med Chem (2016)