Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

[Image: see text] We here describe the first reported comprehensive analysis of Hsp90 paralogue affinity and selectivity in the clinical Hsp90 inhibitor chemotypes. This has been possible through the development of a versatile experimental assay based on a new FP-probe (16a) that we both describe he...

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Bibliografiset tiedot
Päätekijät: Taldone, Tony, Patel, Pallav D., Patel, Maulik, Patel, Hardik J., Evans, Christopher E., Rodina, Anna, Ochiana, Stefan, Shah, Smit K., Uddin, Mohammad, Gewirth, Daniel, Chiosis, Gabriela
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985615/
https://ncbi.nlm.nih.gov/pubmed/23965125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400619b
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