Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronic inflammatory conditions, diabetes, coronary thrombosis, and stroke. We have recently identified a novel alloste...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Patel, Hardik J., Patel, Pallav D., Ochiana, Stefan O., Yan, Pengrong, Sun, Weilin, Patel, Maulik R., Shah, Smit K., Tramentozzi, Elisa, Brooks, James, Bolaender, Alexander, Shrestha, Liza, Stephani, Ralph, Finotti, Paola, Leifer, Cynthia, Li, Zihai, Gewirth, Daniel T., Taldone, Tony, Chiosis, Gabriela
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518544/
https://ncbi.nlm.nih.gov/pubmed/25901531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00197
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