Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronic inflammatory conditions, diabetes, coronary thrombosis, and stroke. We have recently identified a novel alloste...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Med Chem
Hlavní autoři: Patel, Hardik J., Patel, Pallav D., Ochiana, Stefan O., Yan, Pengrong, Sun, Weilin, Patel, Maulik R., Shah, Smit K., Tramentozzi, Elisa, Brooks, James, Bolaender, Alexander, Shrestha, Liza, Stephani, Ralph, Finotti, Paola, Leifer, Cynthia, Li, Zihai, Gewirth, Daniel T., Taldone, Tony, Chiosis, Gabriela
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518544/
https://ncbi.nlm.nih.gov/pubmed/25901531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00197
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky