Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronic inflammatory conditions, diabetes, coronary thrombosis, and stroke. We have recently identified a novel alloste...

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Publicado en:J Med Chem
Main Authors: Patel, Hardik J., Patel, Pallav D., Ochiana, Stefan O., Yan, Pengrong, Sun, Weilin, Patel, Maulik R., Shah, Smit K., Tramentozzi, Elisa, Brooks, James, Bolaender, Alexander, Shrestha, Liza, Stephani, Ralph, Finotti, Paola, Leifer, Cynthia, Li, Zihai, Gewirth, Daniel T., Taldone, Tony, Chiosis, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518544/
https://ncbi.nlm.nih.gov/pubmed/25901531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00197
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