Paralog-selective Hsp90 inhibitors define tumor-specific regulation of Her2

Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancer phenotype is poorly understood. This is in large part because reagents to study paralog-specific functions in...

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Main Authors: Patel, Pallav D., Yan, Pengrong, Seidler, Paul M., Patel, Hardik J., Sun, Weilin, Yang, Chenghua, Que, Nanette S., Taldone, Tony, Finotti, Paola, Stephani, Ralph A., Gewirth, Daniel T., Chiosis, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982621/
https://ncbi.nlm.nih.gov/pubmed/23995768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1335
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