Загрузка...

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity

Hsp90α and Hsp90β are implicated in a number of cancers and neurodegenerative disorders but the lack of selective pharmacological probes confounds efforts to identify their individual roles. Here, we analyzed the binding of an Hsp90α-selective PU compound, PU-11-trans, to the two cytosolic paralogs....

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Proteins
Главные авторы: Huck, John D., Que, Nanette L.S., Sharma, Sahil, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718336/
https://ncbi.nlm.nih.gov/pubmed/31141217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25750
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!