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Design, Synthesis and Evaluation of Small Molecule Hsp90 Probes
A number of compounds from different chemical classes are known to bind competitively to the ATP-pocket of Hsp90 and inhibit its chaperone function. The natural product geldanamycin was the first reported inhibitor of Hsp90 and since then synthetic inhibitors from purine, isoxazole and indazol-4-one...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143825/ https://ncbi.nlm.nih.gov/pubmed/21459002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.03.013 |
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