Design, Synthesis and Evaluation of Small Molecule Hsp90 Probes

A number of compounds from different chemical classes are known to bind competitively to the ATP-pocket of Hsp90 and inhibit its chaperone function. The natural product geldanamycin was the first reported inhibitor of Hsp90 and since then synthetic inhibitors from purine, isoxazole and indazol-4-one...

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Bibliografiske detaljer
Main Authors: Taldone, Tony, Zatorska, Danuta, Patel, Pallav D., Zong, Hongliang, Rodina, Anna, Ahn, James H., Moulick, Kamalika, Guzman, Monica L., Chiosis, Gabriela
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143825/
https://ncbi.nlm.nih.gov/pubmed/21459002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.03.013
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