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Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adu...

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Detalhes bibliográficos
Main Authors: Taldone, Tony, Gillan, Victoria, Sun, Weilin, Rodina, Anna, Patel, Pallav, Maitland, Kirsty, O'Neill, Kerry, Chiosis, Gabriela, Devaney, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886105/
https://ncbi.nlm.nih.gov/pubmed/20559560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000714
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