α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96: A POTENTIAL THERAPEUTIC TARGET FOR CANCER METASTASIS

Integrins play important roles in regulating a diverse array of cellular functions crucial to the initiation, progression, and metastasis of tumors. Previous studies have shown that a majority of integrins are folded by the endoplasmic reticulum chaperone gp96. Here, we demonstrate that the dimeriza...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Hong, Feng, Liu, Bei, Chiosis, Gabriela, Gewirth, Daniel T., Li, Zihai
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689966/
https://ncbi.nlm.nih.gov/pubmed/23671277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468850
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky