gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

Integrins contribute to lymphopoiesis, whereas Toll-like receptors (TLRs) facilitate the myeloid replenishment during inflammation. The combined role of TLRs and integrin on hematopoiesis remains unclear. gp96 (grp94, HSP90b1) is an endoplasmic reticulum master chaperone for multiple TLRs. We report...

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Bibliografiske detaljer
Main Authors: Staron, Matthew, Yang, Yi, Liu, Bei, Li, Janet, Shen, Yuankai, Zúñiga-Pflücker, Juan Carlos, Aguila, Hector L., Goldschneider, Irving, Li, Zihai
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845896/
https://ncbi.nlm.nih.gov/pubmed/19965672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233031
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