gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

Integrins contribute to lymphopoiesis, whereas Toll-like receptors (TLRs) facilitate the myeloid replenishment during inflammation. The combined role of TLRs and integrin on hematopoiesis remains unclear. gp96 (grp94, HSP90b1) is an endoplasmic reticulum master chaperone for multiple TLRs. We report...

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Detalhes bibliográficos
Main Authors: Staron, Matthew, Yang, Yi, Liu, Bei, Li, Janet, Shen, Yuankai, Zúñiga-Pflücker, Juan Carlos, Aguila, Hector L., Goldschneider, Irving, Li, Zihai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845896/
https://ncbi.nlm.nih.gov/pubmed/19965672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233031
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