Energy metabolism in neurodevelopment and medulloblastoma

por Tech, Katherine, Gershon, Timothy R.
Publicado no Transl Pediatr (2015)

A new way to treat brain tumors: Targeting proteins coded by microcephaly genes?: Brain tumors and microcephaly arise from opposing derangements regulating progenitor growth. Drive...

por Lang, Patrick Y., Gershon, Timothy R.
Publicado no Bioessays (2018)

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma

por Tech, Katherine, Deshmukh, Mohanish, Gershon, Timothy R.
Publicado em 2014

Temporally Regulated Neural Crest Transcription Factors Distinguish Neuroectodermal Tumors of Varying Malignancy and Differentiation

por Gershon, Timothy R, Oppenheimer, Orit, Chin, Steven S, Gerald, William L
Publicado em 2005

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum

por Gershon, Timothy R, Crowther, Andrew J, Liu, Hedi, Miller, C Ryan, Deshmukh, Mohanish
Publicado em 2013

Two Receptor Tyrosine Phosphatases of the LAR Family Are Expressed in the Developing Leech by Specific Central Neurons as well as Select Peripheral Neurons, Muscles, and Other Cell...

por Gershon, Timothy R., Baker, Michael W., Nitabach, Michael, Wu, Peter, Macagno, Eduardo R.
Publicado no J Neurosci (1998)

GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma

por Ocasio, Jennifer K., Bates, Rolf Dale P., Rapp, Carolyn D., Gershon, Timothy R.
Publicado no Development (2019)

Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

por Garcia, Idoia, Crowther, Andrew J., Gama, Vivian, Miller, C. Ryan, Deshmukh, Mohanish, Gershon, Timothy R.
Publicado em 2012

Enteric Neural Crest Differentiation in Ganglioneuromas Implicates Hedgehog Signaling in Peripheral Neuroblastic Tumor Pathogenesis

por Gershon, Timothy R., Shirazi, Arash, Qin, Li-Xuan, Gerald, William L., Kenney, Anna M., Cheung, Nai-Kong
Publicado em 2009

Tonic Activation of Bax Primes Neural Progenitors for Rapid Apoptosis through a Mechanism Preserved in Medulloblastoma

por Crowther, Andrew J., Gama, Vivian, Bevilacqua, Ariana, Chang, Sha X., Yuan, Hong, Deshmukh, Mohanish, Gershon, Timothy R.
Publicado em 2013

Erbb4 Is Required for Cerebellar Development and Malignant Phenotype of Medulloblastoma

por Aldaregia, Juncal, Errarte, Peio, Olazagoitia-Garmendia, Ane, Gimeno, Marian, Uriz, Jose Javier, Gershon, Timothy R., Garcia, Idoia, Matheu, Ander
Publicado no Cancers (Basel) (2020)

Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis

por Veleta, Katherine A., Cleveland, Abigail H., Babcock, Benjamin R., He, You-Wen, Hwang, Duhyeong, Sokolsky-Papkov, Marina, Gershon, Timothy R.
Publicado no Cell Death Differ (2020)

ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

por Lang, Patrick Y., Nanjangud, Gouri J., Sokolsky-Papkov, Marina, Shaw, Christine, Hwang, Duhyeong, Parker, Joel S., Kabanov, Alexander V., Gershon, Timothy R.
Publicado no Development (2016)

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

por Gershon, Timothy R, Crowther, Andrew J, Tikunov, Andrey, Garcia, Idoia, Annis, Ryan, Yuan, Hong, Miller, C Ryan, Macdonald, Jeffrey, Olson, James, Deshmukh, Mohanish
Publicado em 2013

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum

por Swahari, Vijay, Nakamura, Ayumi, Baran-Gale, Jeanette, Garcia, Idoia, Crowther, Andrew J., Sons, Robert, Gershon, Timothy R., Hammond, Scott, Sethupathy, Praveen, Deshmukh, Mohanish
Publicado no Cell Rep (2015)

Projected t-SNE for batch correction

por Aliverti, Emanuele, Tilson, Jeffrey L, Filer, Dayne L, Babcock, Benjamin, Colaneri, Alejandro, Ocasio, Jennifer, Gershon, Timothy R, Wilhelmsen, Kirk C, Dunson, David B
Publicado no Bioinformatics (2020)

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

por Knight, Elizabeth R. W., Patel, Esita Y., Flowers, Cornelius A., Crowther, Andrew J., Ting, Jenny P., Miller, C. Ryan, Gershon, Timothy R., Deshmukh, Mohanish
Publicado no Oncogene (2014)

Radiation sensitivity in a preclinical mouse model of medulloblastoma relies on the function of the intrinsic apoptotic pathway

por Crowther, Andrew, Ocasio, Jennifer, Fang, Fang, Meidinger, Jessica, Wu, Jaclyn, Deal, Allison M, Chang, Sha X., Yuan, Hong, Schmid, Ralf, Davis, Ian, Gershon, Timothy R.
Publicado no Cancer Res (2016)

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile

por Malawsky, Daniel Shiloh, Weir, Seth J., Ocasio, Jennifer Karin, Babcock, Benjamin, Dismuke, Taylor, Cleveland, Abigail H., Donson, Andrew M., Vibhakar, Rajeev, Wilhelmsen, Kirk, Gershon, Timothy R.
Publicado no Commun Biol (2021)

Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity

por Hwang, Duhyeong, Dismuke, Taylor, Tikunov, Andrey, Rosen, Elias P., Kagel, John R., Ramsey, Jacob D., Lim, Chaemin, Zamboni, William, Kabanov, Alexander V., Gershon, Timothy R., Sokolsky-Papkov, Marina
Publicado no Nanomedicine (2020)