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ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC’s role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pedia...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Knight, Elizabeth R. W., Patel, Esita Y., Flowers, Cornelius A., Crowther, Andrew J., Ting, Jenny P., Miller, C. Ryan, Gershon, Timothy R., Deshmukh, Mohanish
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520702/
https://ncbi.nlm.nih.gov/pubmed/24469054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.577
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