Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

Neurogenesis requires negative regulation through differentiation of progenitors or their programmed cell death (PCD). Growth regulation is particularly important in the postnatal cerebellum, where excessive progenitor proliferation promotes medulloblastoma, the most common malignant brain tumor in...

Full description

Saved in:

Bibliographic Details
Main Authors:	Garcia, Idoia, Crowther, Andrew J., Gama, Vivian, Miller, C. Ryan, Deshmukh, Mohanish, Gershon, Timothy R.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3449008/ https://ncbi.nlm.nih.gov/pubmed/22710714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.248
Tags:	Add Tag No Tags, Be the first to tag this record!

Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

Similar Items