Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

Neurogenesis requires negative regulation through differentiation of progenitors or their programmed cell death (PCD). Growth regulation is particularly important in the postnatal cerebellum, where excessive progenitor proliferation promotes medulloblastoma, the most common malignant brain tumor in...

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Bibliografiset tiedot
Päätekijät: Garcia, Idoia, Crowther, Andrew J., Gama, Vivian, Miller, C. Ryan, Deshmukh, Mohanish, Gershon, Timothy R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449008/
https://ncbi.nlm.nih.gov/pubmed/22710714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.248
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