ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC’s role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pedia...

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Pubblicato in:Oncogene
Autori principali: Knight, Elizabeth R. W., Patel, Esita Y., Flowers, Cornelius A., Crowther, Andrew J., Ting, Jenny P., Miller, C. Ryan, Gershon, Timothy R., Deshmukh, Mohanish
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520702/
https://ncbi.nlm.nih.gov/pubmed/24469054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.577
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