Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity

We report a nanoparticle formulation of the SHH-pathway inhibitor vismodegib that improves efficacy for medulloblastoma, while reducing toxicity. Limited blood–brain barrier (BBB) penetration and dose-limiting extraneural toxicities complicate systemic therapies for brain tumors. Vismodegib is FDA-a...

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Publicat a:Nanomedicine
Autors principals: Hwang, Duhyeong, Dismuke, Taylor, Tikunov, Andrey, Rosen, Elias P., Kagel, John R., Ramsey, Jacob D., Lim, Chaemin, Zamboni, William, Kabanov, Alexander V., Gershon, Timothy R., Sokolsky-Papkov, Marina
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160025/
https://ncbi.nlm.nih.gov/pubmed/33259959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2020.102345
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