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Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity
We report a nanoparticle formulation of the SHH-pathway inhibitor vismodegib that improves efficacy for medulloblastoma, while reducing toxicity. Limited blood–brain barrier (BBB) penetration and dose-limiting extraneural toxicities complicate systemic therapies for brain tumors. Vismodegib is FDA-a...
Kaydedildi:
| Yayımlandı: | Nanomedicine |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8160025/ https://ncbi.nlm.nih.gov/pubmed/33259959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2020.102345 |
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