CADD-06. VISMODEGIB LOADED POLYOXAZOLINE (POx) MICELLES ENHANCE EFFICACY OF VISMODEGIB AND PROLONG MICE SURVIVAL, EMPHASIZE POTENTIAL OF POx MICELLES TO IMPROVE DRUG DELIVERY TO BRAIN TUMORS

For the roughly 30% of medulloblastoma patients with SHH-subgroup tumors, drugs that disrupt SHH signaling offer the potential of improved efficacy with reduced toxicity compared to current, non-targeted treatment. The FDA-approved SMO inhibitor vismodegib, has been shown to be safe and effective fo...

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Publicado no:Neuro Oncol
Main Authors: Hwang, Duhyeong, Lim, Chaemin, Zhao, Yuling, Liu, Hedi, Kabanov, Alexander V, Gershon, Timothy, Sokolsky-Papkov, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216792/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1155
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