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Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs
Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable polymeric micelle-based delivery of poorly soluble drugs. We built models predicting both drug loading efficiency (LE) and loading capacity (LC) using novel des...
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| Pubblicato in: | Sci Adv |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Association for the Advancement of Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594770/ https://ncbi.nlm.nih.gov/pubmed/31249867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav9784 |
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