Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs

Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable polymeric micelle-based delivery of poorly soluble drugs. We built models predicting both drug loading efficiency (LE) and loading capacity (LC) using novel des...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Alves, Vinicius M., Hwang, Duhyeong, Muratov, Eugene, Sokolsky-Papkov, Marina, Varlamova, Ekaterina, Vinod, Natasha, Lim, Chaemin, Andrade, Carolina H., Tropsha, Alexander, Kabanov, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594770/
https://ncbi.nlm.nih.gov/pubmed/31249867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav9784
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