Radiation sensitivity in a preclinical mouse model of medulloblastoma relies on the function of the intrinsic apoptotic pathway

While treatments that induce DNA damage are commonly used as anti-cancer therapies, the mechanisms through which DNA damage produces a therapeutic response are incompletely understood. Here we have tested whether medulloblastomas must be competent for apoptosis to be sensitive to radiation therapy....

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Crowther, Andrew, Ocasio, Jennifer, Fang, Fang, Meidinger, Jessica, Wu, Jaclyn, Deal, Allison M, Chang, Sha X., Yuan, Hong, Schmid, Ralf, Davis, Ian, Gershon, Timothy R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891232/
https://ncbi.nlm.nih.gov/pubmed/27197166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0025
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