Molecular targets underlying general anaesthesia

Por Franks, Nicholas P
Publicado em 2006

Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection

Por Dickinson, Robert, Franks, Nicholas P
Publicado em 2010

The effects of hypoxia on the modulation of human TREK-1 potassium channels

Por Caley, Alex J, Gruss, Marco, Franks, Nicholas P
Publicado em 2005

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels

Por MacKenzie, Georgina, Franks, Nicholas P., Brickley, Stephen G.
Publicado no Pflugers Arch (2014)

Molecular Modeling of a Tandem Two Pore Domain Potassium Channel Reveals a Putative Binding Site for General Anesthetics

Por Bertaccini, Edward J., Dickinson, Robert, Trudell, James R., Franks, Nicholas P.
Publicado no ACS Chem Neurosci (2014)

Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABA(A) Receptors

Por Eaton, Megan M., Cao, Lily Q., Chen, Ziwei, Franks, Nicholas P., Evers, Alex S., Akk, Gustav
Publicado no Mol Pharmacol (2015)

Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA(A) Receptors with Different γ Subunits

Por Ye, Zhiwen, Yu, Xiao, Houston, Catriona M., Aboukhalil, Zahra, Franks, Nicholas P., Wisden, William, Brickley, Stephen G.
Publicado no Front Cell Neurosci (2017)

Altered Activity in the Central Medial Thalamus Precedes Changes in the Neocortex during Transitions into Both Sleep and Propofol Anesthesia

Por Baker, Rowan, Gent, Thomas C., Yang, Qianzi, Parker, Susan, Vyssotski, Alexei L., Wisden, William, Brickley, Stephen G., Franks, Nicholas P.
Publicado em 2014

Activation and modulation of recombinant glycine and GABA(A) receptors by 4‐halogenated analogues of propofol

Por Germann, Allison L, Shin, Daniel J, Manion, Brad D, Edge, Christopher J, Smith, Edward H, Franks, Nicholas P, Evers, Alex S, Akk, Gustav
Publicado no Br J Pharmacol (2016)

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons

Por Uygun, David S., Ye, Zhiwen, Zecharia, Anna Y., Harding, Edward C., Yu, Xiao, Yustos, Raquel, Vyssotski, Alexei L., Brickley, Stephen G., Franks, Nicholas P., Wisden, William
Publicado no J Neurosci (2016)

GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of Consciousness

Por Zecharia, Anna Y., Yu, Xiao, Götz, Thomas, Ye, Zhiwen, Carr, David R., Wulff, Peer, Bettler, Bernhard, Vyssotski, Alexei L., Brickley, Stephen G., Franks, Nicholas P., Wisden, William
Publicado em 2012

An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action

Por Pang, Daniel S. J., Robledo, Christian J., Carr, David R., Gent, Thomas C., Vyssotski, Alexei L., Caley, Alex, Zecharia, Anna Y., Wisden, William, Brickley, Stephen G., Franks, Nicholas P.
Publicado em 2009

A propofol binding site on mammalian GABA(A) receptors identified by photolabeling

Por Yip, Grace M S, Chen, Zi-Wei, Edge, Christopher J, Smith, Edward H, Dickinson, Robert, Hohenester, Erhard, Townsend, R Reid, Fuchs, Karoline, Sieghart, Werner, Evers, Alex S, Franks, Nicholas P
Publicado em 2013

Xenon improves neurological outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury

Por Campos-Pires, Rita, Armstrong, Scott P, Sebastiani, Anne, Luh, Clara, Gruss, Marco, Radyushkin, Konstantin, Hirnet, Tobias, Werner, Christian, Engelhard, Kristin, Franks, Nicholas P, Thal, Serge C, Dickinson, Robert
Publicado no Crit Care Med (2015)

Are Extrasynaptic GABA(A) Receptors Important Targets for Sedative/Hypnotic Drugs?

Por Houston, Catriona M., McGee, Thomas P., MacKenzie, Georgina, Troyano-Cuturi, Kevin, Rodriguez, Pablo Mateos, Kutsarova, Elena, Diamanti, Efthymia, Hosie, Alastair M., Franks, Nicholas P., Brickley, Stephen G.
Publicado no J Neurosci (2012)

Staying awake – a genetic region that hinders α(2) adrenergic receptor agonist-induced sleep

Por Gelegen, Cigdem, Gent, Thomas C, Ferretti, Valentina, Zhang, Zhe, Yustos, Raquel, Lan, Fei, Yang, Qianzi, Overington, Dorothy W U, Vyssotski, Alexei L, van Lith, Hein A, Wisden, William, Franks, Nicholas P
Publicado em 2014

Wakefulness Is Governed by GABA and Histamine Cotransmission

Por Yu, Xiao, Ye, Zhiwen, Houston, Catriona M., Zecharia, Anna Y., Ma, Ying, Zhang, Zhe, Uygun, David S., Parker, Susan, Vyssotski, Alexei L., Yustos, Raquel, Franks, Nicholas P., Brickley, Stephen G., Wisden, William
Publicado no Neuron (2015)

Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture

Por Yu, Xiao, Zecharia, Anna, Zhang, Zhe, Yang, Qianzi, Yustos, Raquel, Jager, Polona, Vyssotski, Alexei L., Maywood, Elizabeth S., Chesham, Johanna E., Ma, Ying, Brickley, Stephen G., Hastings, Michael H., Franks, Nicholas P., Wisden, William
Publicado no Curr Biol (2014)

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α(2) adrenergic agonists

Por Zhang, Zhe, Ferretti, Valentina, Güntan, İlke, Moro, Alessandro, Steinberg, Eleonora A., Ye, Zhiwen, Zecharia, Anna Y., Yu, Xiao, Vyssotski, Alexei L., Brickley, Stephen G., Yustos, Raquel, Pillidge, Zoe E., Harding, Edward C., Wisden, William, Franks, Nicholas P.
Publicado no Nat Neurosci (2015)

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled...

Por Azzopardi, Denis, Robertson, Nicola J, Bainbridge, Alan, Cady, Ernest, Charles-Edwards, Geoffrey, Deierl, Aniko, Fagiolo, Gianlorenzo, Franks, Nicholas P, Griffiths, James, Hajnal, Joseph, Juszczak, Edmund, Kapetanakis, Basil, Linsell, Louise, Maze, Mervyn, Omar, Omar, Strohm, Brenda, Tusor, Nora, Edwards, A David
Publicado no Lancet Neurol (2016)