A propofol binding site on mammalian GABA(A) receptors identified by photolabeling

Propofol is the most important intravenous general anesthetic in current clinical use. It acts by potentiating GABA(A) receptors, but where it binds to this receptor is not known and has been a matter of some controversy. We have synthesized a novel propofol analogue photolabeling reagent that has a...

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Detalhes bibliográficos
Main Authors: Yip, Grace M S, Chen, Zi-Wei, Edge, Christopher J, Smith, Edward H, Dickinson, Robert, Hohenester, Erhard, Townsend, R Reid, Fuchs, Karoline, Sieghart, Werner, Evers, Alex S, Franks, Nicholas P
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951778/
https://ncbi.nlm.nih.gov/pubmed/24056400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1340
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