Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons

Zolpidem, a GABA(A) receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors. Compared with natural NREM sleep, zolpidem also decreases the...

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Publicat a:J Neurosci
Autors principals: Uygun, David S., Ye, Zhiwen, Zecharia, Anna Y., Harding, Edward C., Yu, Xiao, Yustos, Raquel, Vyssotski, Alexei L., Brickley, Stephen G., Franks, Nicholas P., Wisden, William
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148237/
https://ncbi.nlm.nih.gov/pubmed/27807161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3714-15.2016
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