Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start o...

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Vydáno v:Sleep
Hlavní autoři: Yu, Xiao, Ma, Ying, Harding, Edward C, Yustos, Raquel, Vyssotski, Alexei L, Franks, Nicholas P, Wisden, William
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Basic Science of Sleep and Circadian Rhythms
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://ncbi.nlm.nih.gov/pubmed/30722053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsz031
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