Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start o...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Yu, Xiao, Ma, Ying, Harding, Edward C, Yustos, Raquel, Vyssotski, Alexei L, Franks, Nicholas P, Wisden, William
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Basic Science of Sleep and Circadian Rhythms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://ncbi.nlm.nih.gov/pubmed/30722053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsz031
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