Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start o...

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Bibliografski detalji
Izdano u:Sleep
Glavni autori: Yu, Xiao, Ma, Ying, Harding, Edward C, Yustos, Raquel, Vyssotski, Alexei L, Franks, Nicholas P, Wisden, William
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Basic Science of Sleep and Circadian Rhythms
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://ncbi.nlm.nih.gov/pubmed/30722053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsz031
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