Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sleep
Hauptverfasser: Yu, Xiao, Ma, Ying, Harding, Edward C, Yustos, Raquel, Vyssotski, Alexei L, Franks, Nicholas P, Wisden, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Basic Science of Sleep and Circadian Rhythms
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://ncbi.nlm.nih.gov/pubmed/30722053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsz031
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