NEDD8 and HDACs: promising cotargets in AML

Por Bhalla, Kapil N., Fiskus, Warren
Publicado no Blood (2016)

Targeting cistrome and dysregulated transcriptome of post-MPN sAML

Por Verstovsek, Srdan, Fiskus, Warren, Manshouri, Taghi, Bhalla, Kapil N.
Publicado no Oncotarget (2017)

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer

Por Venkannagari, Sreedhar, Fiskus, Warren, Peth, Karissa, Atadja, Peter, Hidalgo, Manuel, Maitra, Anirban, Bhalla, Kapil N.
Publicado em 2012

Role of acetylation and extra-cellular location of heat shock protein 90α in tumor cell invasion

Por Yang, Yonghua, Rao, Rehka, Shen, Jie, Tang, Yun, Fiskus, Warren, Nechtman, John, Atadja, Peter, Bhalla, Kapil
Publicado em 2008

EVI1 dysregulation: impact on biology and therapy of myeloid malignancies

Por Birdwell, Christine, Fiskus, Warren, Kadia, Tapan M., DiNardo, Courtney D., Mill, Christopher P., Bhalla, Kapil N.
Publicado no Blood Cancer J (2021)

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Por Yang, Yonghua, Fiskus, Warren, Yong, Bao, Atadja, Peter, Takahashi, Yoshinori, Pandita, Tej K., Wang, Hong-Gang, Bhalla, Kapil N.
Publicado em 2013

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

Por Fiskus, Warren, Sharma, Sunil, Shah, Bhavin, Portier, Bryce P., Devaraj, Santhana G. T., Liu, Ka, Iyer, Swaminathan P., Bearss, David, Bhalla, Kapil N.
Publicado no Leukemia (2014)

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist

Por Devaraj, Santhana G. T., Fiskus, Warren, Shah, Bhavin, Qi, Jun, Sun, Baohua, Iyer, Swaminathan P, Sharma, Sunil, Bradner, James E., Bhalla, Kapil N.
Publicado no Leukemia (2015)

BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD

Por Fiskus, Warren, Sharma, Sunil, Qi, Jun, Shah, Bhavin, Devaraj, Santhana G. T., Leveque, Christopher, Portier, Bryce P., Iyer, Swaminathan, Bradner, James E., Bhalla, Kapil N.
Publicado em 2014

Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

Por Fiskus, Warren, Sharma, Sunil, Saha, Saikat, Shah, Bhavin, Devaraj, Santhana G. T., Sun, Baohua, Horrigan, Stephen, Leveque, Christopher, Zu, Youli, Iyer, Swaminathan, Bhalla, Kapil N.
Publicado no Leukemia (2014)

Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells

Por Rao, Rekha, Nalluri, Srilatha, Fiskus, Warren, Balusu, Ramesh, Joshi, Atul, Mudunuru, Uma, Buckley, Kathleen M., Robbins, Kelly, Ustun, Celalettin, Reuther, Gary W., Bhalla, Kapil N.
Publicado em 2010

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate

Por Hu, Yumin, Lu, Weiqin, Chen, Gang, Zhang, Hui, Jia, Yu, Wei, Yue, Yang, Hui, Zhang, Wan, Fiskus, Warren, Bhalla, Kapil, Keating, Michael, Huang, Peng, Garcia-Manero, Guillermo
Publicado em 2010

Superior efficacy of a combined epigenetic therapy against human Mantle Cell Lymphoma (MCL) cells

Por Fiskus, Warren, Rao, Rekha, Balusu, Ramesh, Ganguly, Siddhartha, Tao, Jianguo, Sotomayor, Eduardo, Mudunuru, Uma, Smith, Jacqueline E., Hembruff, Stacey L., Atadja, Peter, Marquez, Victor E., Bhalla, Kapil
Publicado em 2012

Role of C/EBP homologous protein (CHOP) in Panobinostat-mediated potentiation of Bortezomib-induced lethal ER stress in Mantle Cell Lymphoma cells

Por Rao, Rekha, Nalluri, Srilatha, Fiskus, Warren, Savoie, Andrew, Buckley, Kathleen M, Ha, Kyungsoo, Balusu, Ramesh, Joshi, Atul, Coothankandaswamy, Veena, Tao, Jianguo, Sotomayor, Eduardo, Atadja, Peter, Bhalla, Kapil N.
Publicado em 2010

miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation

Por Eedunuri, Vijay Kumar, Rajapakshe, Kimal, Fiskus, Warren, Geng, Chuandong, Chew, Sue Anne, Foley, Christopher, Shah, Shrijal S., Shou, John, Mohamed, Junaith S., Coarfa, Cristian, O'Malley, Bert W., Mitsiades, Nicholas
Publicado no Mol Endocrinol (2015)

Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer

Por Coarfa, Cristian, Fiskus, Warren, Eedunuri, Vijay Kumar, Rajapakshe, Kimal, Foley, Christopher, Chew, Sue Anne, Shah, Shrijal S., Geng, Chuandong, Shou, John, Mohamed, Junaith S., O’Malley, Bert W., Mitsiades, Nicholas
Publicado no Oncogene (2015)

Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells

Por Fiskus, Warren, Buckley, Kate, Rao, Rekha, Mandawat, Aditya, Yang, Yonghua, Joshi, Rajeshree, Wang, Yongchao, Balusu, Ramesh, Chen, Jianguang, Koul, Sanjay, Joshi, Atul, Upadhyay, Sunil, Atadja, Peter, Bhalla, Kapil N.
Publicado em 2009

Histone deacetylase inhibitor treatment induces ‘BRCAness’ and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

Por Ha, Kyungsoo, Fiskus, Warren, Choi, Dong Soon, Bhaskara, Srividya, Cerchietti, Leandro, Devaraj, Santhana G. T., Shah, Bhavin, Sharma, Sunil, Chang, Jenny C., Melnick, Ari M., Hiebert, Scott, Bhalla, Kapil N.
Publicado em 2014

SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents

Por Fiskus, Warren, Coothankandaswamy, Veena, Chen, Jianguang, Ma, Hongwei, Ha, Kyungsoo, Saenz, Dyana T., Krieger, Stephanie S., Mill, Christopher P., Sun, Baohua, Huang, Peng, Mumm, Jeffrey S., Melnick, Ari M., Bhalla, Kapil N.
Publicado no Cancer Res (2016)

Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells

Por Fiskus, Warren, Verstovsek, Srdan, Manshouri, Taghi, Rao, Rekha, Balusu, Ramesh, Venkannagari, Sreedhar, Nalabothula, Narasimha Rao, Ha, Kyungsoo, Smith, Jacqueline E., Hembruff, Stacey, Abhyankar, Sunil, McGuirk, Joseph, Bhalla, Kapil N.
Publicado em 2011