Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

The canonical WNT-β-catenin pathway is essential for self-renewal, growth and survival of AML stem/blast progenitor cells (BPCs). Deregulated WNT signaling inhibits degradation of β-catenin, causing increased nuclear translocation and co-factor activity of β-catenin with the transcriptional regulato...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Fiskus, Warren, Sharma, Sunil, Saha, Saikat, Shah, Bhavin, Devaraj, Santhana G. T., Sun, Baohua, Horrigan, Stephen, Leveque, Christopher, Zu, Youli, Iyer, Swaminathan, Bhalla, Kapil N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456205/
https://ncbi.nlm.nih.gov/pubmed/25482131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.340
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