Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

The histone demethylase LSD1 (KDM1A) demethylates mono- and di-methylated (Me2) lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and confers a poor prognosis in AML. Here, treatment with the novel LSD1 antagonist SP2509 attenuated the binding of LSD1 with the co-repressor CoRE...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Leukemia
Egile Nagusiak: Fiskus, Warren, Sharma, Sunil, Shah, Bhavin, Portier, Bryce P., Devaraj, Santhana G. T., Liu, Ka, Iyer, Swaminathan P., Bearss, David, Bhalla, Kapil N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739780/
https://ncbi.nlm.nih.gov/pubmed/24699304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.119
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