Superior efficacy of a combined epigenetic therapy against human Mantle Cell Lymphoma (MCL) cells

A deregulated epigenome contributes to the transformed phenotype of Mantle Cell Lymphoma (MCL). This involves activity of the PRC (polycomb repressive complex) 2, containing three core proteins EZH2, SUZ12 and EED, in which the SET domain of EZH2 mediates the histone methyltransferase activity. This...

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Hauptverfasser: Fiskus, Warren, Rao, Rekha, Balusu, Ramesh, Ganguly, Siddhartha, Tao, Jianguo, Sotomayor, Eduardo, Mudunuru, Uma, Smith, Jacqueline E., Hembruff, Stacey L., Atadja, Peter, Marquez, Victor E., Bhalla, Kapil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113119/
https://ncbi.nlm.nih.gov/pubmed/22932665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0873
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