Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells

PURPOSE: We determined the activity of heat shock protein (hsp) 90 inhibitor (HI), and/or JAK2 tyrosine kinase inhibitor (TKI) against JAK2-V617F-expressing cultured mouse (Ba/F3-JAK2-V617F) and human (HEL92.1.7 and UKE1) or primary human CD34+ myeloproliferative neoplasm (MPN) cells. EXPERIMENTAL D...

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Detalhes bibliográficos
Main Authors: Fiskus, Warren, Verstovsek, Srdan, Manshouri, Taghi, Rao, Rekha, Balusu, Ramesh, Venkannagari, Sreedhar, Nalabothula, Narasimha Rao, Ha, Kyungsoo, Smith, Jacqueline E., Hembruff, Stacey, Abhyankar, Sunil, McGuirk, Joseph, Bhalla, Kapil N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743080/
https://ncbi.nlm.nih.gov/pubmed/21976548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1541
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