SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents

SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors where it is mutated, however, the critical substrates mediating its antitumor activity are not fully defined. Here we demonstrate that SIRT2 binds, deacetylates and inhibits the peroxidase activity of the anti-o...

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Publié dans:Cancer Res
Auteurs principaux: Fiskus, Warren, Coothankandaswamy, Veena, Chen, Jianguang, Ma, Hongwei, Ha, Kyungsoo, Saenz, Dyana T., Krieger, Stephanie S., Mill, Christopher P., Sun, Baohua, Huang, Peng, Mumm, Jeffrey S., Melnick, Ari M., Bhalla, Kapil N.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345574/
https://ncbi.nlm.nih.gov/pubmed/27503926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0126
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