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Role of acetylation and extra-cellular location of heat shock protein 90α in tumor cell invasion
Heat shock protein (hsp) 90 is an ATP-dependent molecular chaperone, which maintains the active conformation of client oncoproteins in cancer cells. An isoform, hsp90α, promotes extra-cellular maturation of matrix metalloproteinase (MMP)-2 involved in tumor invasion and metastasis. Knockdown of hist...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665713/ https://ncbi.nlm.nih.gov/pubmed/18559531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0644 |
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