Role of acetylation and extra-cellular location of heat shock protein 90α in tumor cell invasion

Heat shock protein (hsp) 90 is an ATP-dependent molecular chaperone, which maintains the active conformation of client oncoproteins in cancer cells. An isoform, hsp90α, promotes extra-cellular maturation of matrix metalloproteinase (MMP)-2 involved in tumor invasion and metastasis. Knockdown of hist...

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Hlavní autoři: Yang, Yonghua, Rao, Rehka, Shen, Jie, Tang, Yun, Fiskus, Warren, Nechtman, John, Atadja, Peter, Bhalla, Kapil
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665713/
https://ncbi.nlm.nih.gov/pubmed/18559531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0644
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