Marburg Virus VP24 Protein Relieves Suppression of the NF–κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1

Por Edwards, Megan R., Basler, Christopher F.
Publicado no J Infect Dis (2015)

Current status of small molecule drug development for Ebola virus and other filoviruses

Por Edwards, Megan R., Basler, Christopher F.
Publicado no Curr Opin Virol (2019)

Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors

Por Keiffer, Timothy R., Ciancanelli, Michael J., Edwards, Megan R., Basler, Christopher F.
Publicado no mSphere (2020)

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication

Por Edwards, Megan R., Pietzsch, Colette, Vausselin, Thibaut, Shaw, Megan L., Bukreyev, Alexander, Basler, Christopher F.
Publicado no ACS Infect Dis (2015)

Impact of Měnglà Virus Proteins on Human and Bat Innate Immune Pathways

Por Williams, Caroline G., Gibbons, Joyce Sweeney, Keiffer, Timothy R., Luthra, Priya, Edwards, Megan R., Basler, Christopher F.
Publicado no J Virol (2020)

Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression

Por Edwards, Megan R., Hoad, Mikayla, Tsimbalyuk, Sofiya, Menicucci, Andrea R., Messaoudi, Ilhem, Forwood, Jade K., Basler, Christopher F.
Publicado no J Virol (2020)

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability

Por Schwarz, Toni M., Edwards, Megan R., Diederichs, Audrey, Alinger, Joshua B., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F.
Publicado no J Virol (2017)

Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses

Por Johnson, Britney, Li, Jing, Adhikari, Jagat, Edwards, Megan R., Zhang, Hao, Schwarz, Toni, Leung, Daisy W., Basler, Christopher F., Gross, Michael L., Amarasinghe, Gaya K.
Publicado no J Mol Biol (2016)

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Por Smith, Kate M., Tsimbalyuk, Sofiya, Edwards, Megan R., Cross, Emily M., Batra, Jyoti, Soares da Costa, Tatiana P., Aragão, David, Basler, Christopher F., Forwood, Jade K.
Publicado no Nat Commun (2018)

The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway

Por Edwards, Megan R., Johnson, Britney, Mire, Chad E., Xu, Wei, Shabman, Reed S., Speller, Lauren N., Leung, Daisy W., Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.
Publicado em 2014

Structural basis for Marburg virus VP35–mediated immune evasion mechanisms

Por Ramanan, Parameshwaran, Edwards, Megan R., Shabman, Reed S., Leung, Daisy W., Endlich-Frazier, Ariel C., Borek, Dominika M., Otwinowski, Zbyszek, Liu, Gai, Huh, Juyoung, Basler, Christopher F., Amarasinghe, Gaya K.
Publicado em 2012

Differential regulation of interferon responses by Ebola and Marburg virus VP35 proteins

Por Edwards, Megan R., Liu, Gai, Mire, Chad E., Sureshchandra, Suhas, Luthra, Priya, Yen, Benjamin, Shabman, Reed S., Leung, Daisy W., Messaoudi, Ilhem, Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.
Publicado no Cell Rep (2016)

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

Por Luthra, Priya, Naidoo, Jacinth, Pietzsch, Colette A., De, Sampriti, Khadka, Sudip, Anantpadma, Manu, Williams, Caroline G., Edwards, Megan R., Davey, Robert A., Bukreyev, Alexander, Ready, Joseph M., Basler, Christopher F.
Publicado no Antiviral Res (2018)

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

Por Edwards, Megan R., Liu, Hejun, Shabman, Reed S., Ginell, Garrett M., Luthra, Priya, Ramanan, Parmeshwaran, Keefe, Lisa J., Köllner, Bernd, Amarasinghe, Gaya K., Taylor, Derek J., Leung, Daisy W., Basler, Christopher F.
Publicado no Cell Rep (2018)

Small molecule compounds that inhibit antioxidant response gene expression in an inducer-dependent manner

Por Edwards, Megan R., Liu, Gai, De, Sampriti, Sourimant, Julien, Pietzsch, Colette, Johnson, Britney, Amarasinghe, Gaya K., Leung, Daisy W., Bukreyev, Alexander, Plemper, Richard K., Aron, Zachary, Bowlin, Terry L., Moir, Donald T., Basler, Christopher F.
Publicado no ACS Infect Dis (2020)

Ebola virus VP24 targets a unique NLS-binding site on karyopherin5 to selectively compete with nuclear import of phosphorylated STAT1

Por Xu, Wei, Edwards, Megan R., Borek, Dominika M., Feagins, Alicia R., Mittal, Anuradha, Alinger, Joshua B., Berry, Kayla N., Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J., Pappu, Rohit V., Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.
Publicado em 2014

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses

Por Chatterjee, Srirupa, Luthra, Priya, Esaulova, Ekaterina, Agapov, Eugene, Yen, Benjamin C., Borek, Dominika M., Edwards, Megan R., Mittal, Anuradha, Jordan, David S., Ramanan, Parameshwar, Moore, Martin L., Pappu, Rohit V., Holtzman, Michael J., Artyomov, Max, Basler, Christopher F., Amarasinghe, Gaya K., Leung, Daisy W.
Publicado no Nat Microbiol (2017)