Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

SUMMARY: Non-retroviral integrated RNA viral sequences (NIRVs) potentially encoding ~280 amino acid homologs to filovirus VP35 proteins are present across the Myotis genus of bats. These are estimated to have been maintained for ~18 million years, indicating their co-option. To address the reasons f...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Edwards, Megan R., Liu, Hejun, Shabman, Reed S., Ginell, Garrett M., Luthra, Priya, Ramanan, Parmeshwaran, Keefe, Lisa J., Köllner, Bernd, Amarasinghe, Gaya K., Taylor, Derek J., Leung, Daisy W., Basler, Christopher F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474348/
https://ncbi.nlm.nih.gov/pubmed/30044983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.045
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