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Basic Residues within the Ebolavirus VP35 Protein Are Required for Its Viral Polymerase Cofactor Function
The ebolavirus (EBOV) VP35 protein binds to double-stranded RNA (dsRNA), inhibits host alpha/beta interferon (IFN-α/β) production, and is an essential component of the viral polymerase complex. Structural studies of the VP35 C-terminal IFN inhibitory domain (IID) identified specific structural featu...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology (ASM)
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950600/ https://ncbi.nlm.nih.gov/pubmed/20686031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00925-10 |
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