Ebola Virus VP35 Interaction with Dynein LC8 Regulates Viral RNA Synthesis

Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct...

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Bibliographic Details
Published in:J Virol
Main Authors: Luthra, Priya, Jordan, David S., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403485/
https://ncbi.nlm.nih.gov/pubmed/25741013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03652-14
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