DRBP76 Associates With Ebola Virus VP35 and Suppresses Viral Polymerase Function

The Zaire Ebola virus (EBOV) protein VP35 is multifunctional; it inhibits IFN-α/β production and functions as a cofactor of the viral RNA polymerase. Mass spectrometry identified the double stranded RNA binding protein 76 (DRBP76/NFAR-1/NF90) as a cellular factor that associates with the VP35 C-term...

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Autors principals: Shabman, Reed S., Leung, Daisy W., Johnson, Joshua, Glennon, Nicole, Gulcicek, Erol E., Stone, Kathryn L., Leung, Lawrence, Hensley, Lisa, Amarasinghe, Gaya K., Basler, Christopher F.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Viral Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218669/
https://ncbi.nlm.nih.gov/pubmed/21987769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir343
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