Basic Residues within the Ebolavirus VP35 Protein Are Required for Its Viral Polymerase Cofactor Function

The ebolavirus (EBOV) VP35 protein binds to double-stranded RNA (dsRNA), inhibits host alpha/beta interferon (IFN-α/β) production, and is an essential component of the viral polymerase complex. Structural studies of the VP35 C-terminal IFN inhibitory domain (IID) identified specific structural featu...

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Bibliographic Details
Main Authors: Prins, Kathleen C., Binning, Jennifer M., Shabman, Reed S., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950600/
https://ncbi.nlm.nih.gov/pubmed/20686031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00925-10
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