Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 compounds for inhibition of an EBOV minigenome (MG) assay that measures the function of the viral polymerase comple...

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Pubblicato in:Antiviral Res
Autori principali: Luthra, Priya, Naidoo, Jacinth, Pietzsch, Colette A., De, Sampriti, Khadka, Sudip, Anantpadma, Manu, Williams, Caroline G., Edwards, Megan R., Davey, Robert A., Bukreyev, Alexander, Ready, Joseph M., Basler, Christopher F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436837/
https://ncbi.nlm.nih.gov/pubmed/30144461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2018.08.012
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