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Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine

Stavudine is a hepatotoxic antiretroviral nucleoside analogue that also inhibits the replication of mitochondrial DNA (mtDNA). To elucidate the mechanism and consequences of mtDNA depletion, we treated HepG2 cells with stavudine and either redoxal, an inhibitor of de novo pyrimidine synthesis, or ur...

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Bibliografiske detaljer
Main Authors: Setzer, Bernhard, Lebrecht, Dirk, Walker, Ulrich A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258259/
https://ncbi.nlm.nih.gov/pubmed/18276780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070613
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