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Mitochondrial DNA Depletion in Rat Liver Induced by Fosalvudine Tidoxil, a Novel Nucleoside Reverse Transcriptase Inhibitor Prodrug

Fosalvudine tidoxil is a prodrug derived from the nucleoside reverse transcriptase inhibitor 3-deoxy-3-fluorothymidine (FLT; alovudine). FLT effectively inhibits resistant human immunodeficiency virus type 1, but its clinical development was stopped due to bone marrow and liver toxicity. In this stu...

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Main Authors: Venhoff, Ana C., Lebrecht, Dirk, Reuss, Frank U., Heckl-Östreicher, Brigitte, Wehr, Roland, Walker, Ulrich A., Venhoff, Nils
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704664/
https://ncbi.nlm.nih.gov/pubmed/19433557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00364-09
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