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Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors

Mitochondrial dysfunction as a consequence of mitochondrial DNA (mtDNA) depletion due to therapy with nucleoside analogue reverse transcriptase inhibitors (NRTI) has been proposed as a pathogenic mechanism leading to lipoatrophy in HIV-infected patients. The aim of our study was to investigate the i...

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Hlavní autoři: Stankov, Metodi V., Lücke, Thomas, Das, Anibh M., Schmidt, Reinhold E., Behrens, Georg M. N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798495/
https://ncbi.nlm.nih.gov/pubmed/19805555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00914-09
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