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Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure

Previous studies showed an increased prevalence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) thumb subdomain polymorphisms Pro272, Arg277, and Thr286 in patients failing therapy with nucleoside analogue combinations. Interestingly, wild-type HIV-1(BH10) RT contains Pro27...

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Autori principali: Betancor, Gilberto, Puertas, Maria C., Nevot, María, Garriga, César, Martínez, Miguel A., Martinez-Picado, Javier, Menéndez-Arias, Luis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976120/
https://ncbi.nlm.nih.gov/pubmed/20733040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00716-10
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