Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway

Nucleoside reverse transcriptase (RT) inhibitors (NRTIs) are the backbone of current antiretroviral treatments. However, the emergence of viral resistance against NRTIs is a major threat to their therapeutic effectiveness. In HIV-1, NRTI resistance-associated mutations either reduce RT-mediated inco...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Álvarez, Mar, Nevot, María, Mendieta, Jesús, Martínez, Miguel A., Menéndez-Arias, Luis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818179/
https://ncbi.nlm.nih.gov/pubmed/29275329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000177
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