Thymidine Analogue Excision and Discrimination Modulated by Mutational Complexes Including Single Amino Acid Deletions of Asp-67 or Thr-69 in HIV-1 Reverse Transcriptase

Single amino acid deletions in the β3-β4 hairpin loop of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been identified in heavily treated patients. The deletion of Asp-67 together with mutations T69G and K70R (Δ67 complex) are usually associated with thymidine analog re...

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Main Authors: Kisic, Mónica, Matamoros, Tania, Nevot, María, Mendieta, Jesús, Martinez-Picado, Javier, Martínez, Miguel A., Menéndez-Arias, Luis
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121480/
https://ncbi.nlm.nih.gov/pubmed/21504903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226100
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