Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

BACKGROUND: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. Secondary mutat...

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Autori principali: Betancor, Gilberto, Garriga, César, Puertas, Maria C, Nevot, María, Anta, Lourdes, Blanco, José L, Pérez-Elías, M Jesús, de Mendoza, Carmen, Martínez, Miguel A, Martinez-Picado, Javier, Menéndez-Arias, Luis
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468358/
https://ncbi.nlm.nih.gov/pubmed/22889300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-68
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