Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility

A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described. In this study, the impact of Leu-214 on r...

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Detalhes bibliográficos
Main Authors: Puertas, Maria Carmen, Buzón, Maria Jose, Artese, Anna, Alcaro, Stefano, Menendez-Arias, Luis, Perno, Carlo Federico, Clotet, Bonaventura, Ceccherini-Silberstein, Francesca, Martinez-Picado, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708641/
https://ncbi.nlm.nih.gov/pubmed/19457988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00487-09
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