Hepatitis C Virus Genetic Variability and the Presence of NS5B Resistance-Associated Mutations as Natural Polymorphisms in Selected Genotypes Could Affect the Response to NS5B Inhibitors

Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed the NS5B polymerase genetic variability in circulating HCV genotypes/subtypes and its impact on the genetic barrier for the development of resistance to clinically relevant nucleoside inhibitors (NIs)/nonnucleoside in...

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Bibliographic Details
Main Authors: Di Maio, V. C., Cento, V., Mirabelli, C., Artese, A., Costa, G., Alcaro, S., Perno, C. F., Ceccherini-Silberstein, F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993261/
https://ncbi.nlm.nih.gov/pubmed/24590484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02386-13
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